HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → methyl N'-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethyl]carbamimidothioate;hydroiodide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | 2-((4-Methyl-5-imidazolyl)methylthio)ethylthiourea | HCID 12718697 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | methyl N'-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethyl]carbamimidothioate;hydroiodide | HCID 178504045 | 62.1% |
Reaction Steps
A mixture of N-[2-((5-methyl-4-imidazolyl)methylthio)ethyl]-thiourea (2.29 g) and methyl iodide (1.56 g) in acetone (45 ml) containing methanol (5 ml) was left at room temperature for 18 hours. Concentration followed by recrystallisation from isopropyl alcohol-petroleum ether (b.p. 60°/80°) gave the title compound (2.3 g) m.p. 128°-131°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04118496 |
| Source dataset | uspto-grants-1978_10 |
| ORD ID | ord-c8fbb896b8dc498cba28661b19a475bb |
| Source note | uspto-grants-1978_10 |