反应详情

温度

50 °C

A solution of 6.8 g. of 2-(chloromethyl)pyrimidine is added dropwise to a solution of 5.2 g. of sodium cyanide in 100 ml. of dimethylsulfoxide. The mixture is heated at 50° C. for 2 hours, then diluted with 150 ml. of 5% aqueous sodium carbonate solution and extracted with ether. The extract is dried and concentrated to give 2-(2-pyrimidyl)acetonitrile.

1. additiondiluted with 150 ml
2. extractionof 5% aqueous sodium carbonate solution and extracted with ether
3. customThe extract is dried
4. concentrationconcentrated