Thionyl Chloride → p-Azidomethylphenylacetyl chloride

HRID 1111748Notes

Reaction equation

HRID 1111748 reaction equation
[N:1]([CH2:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][C:12]([OH:14])=O)=[CH:7][CH:6]=1)=[N+:2]=[N-:3].S(Cl)([Cl:17])=O>>[N:1]([CH2:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][C:12]([Cl:17])=[O:14])=[CH:7][CH:6]=1)=[N+:2]=[N-:3]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 14197001p-Azidomethylphenylacetic acid

Product 1

HCID 20505454p-Azidomethylphenylacetyl chloride

Procedure

By stirring a mixture of the thus obtained p-azidomethylphenylacetic acid in thionyl chloride at room temperature for 20 hours the corresponding acid chloride is obtained after removal of the excess reagent under high vacuum at room temperature.

Workup

  1. customis obtained
  2. customafter removal of the excess reagent under high vacuum at room temperature

Sources & evidence

ORD record
ord-78489d3a7c194200b03815ad5f8c86aa
Source dataset
uspto-grants-1978_10
Patent number
US04118562

Reaction notes

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