HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 3-phenyl-DL-alaninate hydrochloride → N-benzyloxycarbonyl (beta-benzyl)-L-aspartyl-L-phenylalanine methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 3-phenyl-DL-alaninate hydrochloride | HCID 3084017 | — |
| Reactant | N-carbobenzoxy-beta-benzyl-L-aspartic acid | HCID 53769026 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-benzyloxycarbonyl (beta-benzyl)-L-aspartyl-L-phenylalanine methyl ester | HCID 14876780 | 45.8% |
Reaction Steps
The process of Example 51 was repeated except that 357 mg (1.00 mmol) of N-benzyloxycarbonyl-(β-benzyl)-L-aspartic acid and 431 mg (2.00 mmol) of D,L-phenylalanine methyl ester hydrochloride were reacted. As a result, a 238 mg amount (yield of 45.8%) of N-benzyloxycarbonyl-(β-benzyl)-L-aspartyl-L-phenylalanine methyl ester having an [α]D20 = -13.2 (C=1.0 dimethylformamide) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04119493 |
| Source dataset | uspto-grants-1978_10 |
| ORD ID | ord-a821198fce544eb7a337eaa9152cb47f |
| Source note | uspto-grants-1978_10 |