p-Toluenesulfonic acid monohydrate → HCID 86736058, compound

Participants

Reaction Steps

t-Butyloxy-glycyl-L-proline 4-phenylazo-1-naphtylamide (1.0 g, 0.002 mole) was treated with p-toluenesulfonic acid monohydrate (0.76 g, 0.004 mole), and the reaction mixture was worked up as in Example 18. The glycyl-L-proline 4-phenylazo-1-naphthylamide tosylate thus obtained was dissolved in methanol, and neutralized with 5% sodium hydrogen carbonate solution to precipitate the product. The precipitate was were removed by filtration, washed with water, dried, and recrystallized from methanol-water.

Provenance & Evidence