Sodium borohydride → 2-Amino-5-[2-(tert-butylamino)-1-hydroxyethyl]-3-chlorobenzonitrile

HRID 1111959Notes

Reaction equation

[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[CH:6][C:5]([C:10](=[O:17])[CH2:11][NH:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[CH:4][C:3]=1[Cl:18].[BH4-].[Na+]>>[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[CH:6][C:5]([CH:10]([OH:17])[CH2:11][NH:12][C:13]([CH3:14])([CH3:15])[CH3:16])=[CH:4][C:3]=1[Cl:18]

Participants

Reactant 2

HCID 4311764Sodium borohydride

HCID 13355790HCID 13355790, compound

Product 1

HCID 420052-Amino-5-[2-(tert-butylamino)-1-hydroxyethyl]-3-chlorobenzonitrile

Procedure

m.p. 125°-133° C., was prepared from 4'-amino-3'-chloro-5'-cyano-2-tert.butylamino-acetophenone and sodium borohydride analogous to Example 2.

Sources & evidence

ORD record: ord-b6a30c6bb75f4235aa84e1cffea80291
Source dataset: uspto-grants-1978_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04119710

Reaction notes

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