反应详情

Ethyl-3-hydroxy-3-methyl-n-nonanoate (25 g) was refluxed for 3 hours with a 10% solution of potassium hydroxide in dry ethanol (210 ml). The ethanol was evaporated in vacuo and the residue was treated with water (100 ml). The aqueous solution was washed with ether then was acidified (ice-bath cooling) with dilute hydrochloric acid. The oil that separated was extracted into ether. The ether solution was washed with brine then was dried over magnesium sulphate and evaporated to give a light yellow oil. This was vacuum distilled to yield 3-hydroxy-3-methyl-n-nonanoic acid as a clear syrup (18.1g).

1. customThe ethanol was evaporated in vacuo
2. additionthe residue was treated with water (100 ml)
3. washThe aqueous solution was washed with ether
4. temperature(ice-bath cooling) with dilute hydrochloric acid
5. customThe oil that separated
6. extractionwas extracted into ether
7. washThe ether solution was washed with brine
8. dry with materialthen was dried over magnesium sulphate
9. customevaporated
10. customto give a light yellow oil
11. distillationThis was vacuum distilled