HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroacetic Acid → 2-(4-Oxo-1,4-dihydroquinolin-1-yl)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroacetic Acid | HCID 300 | — |
| Reactant | HCID 178526978 | HCID 178526978 | — |
| Solvent | Potassium Hydroxide | HCID 14797 | — |
| Product | 2-(4-Oxo-1,4-dihydroquinolin-1-yl)acetic acid | HCID 22766108 | 17.2% |
Reaction Steps
4-Hydroxyquinoline trihydrate (20 g., 0.2 mole) is dissolved in a 50% aqueous potassium hydroxide solution and chloroacetic acid (20 g., 0.2 mole) is incrementally added. The resulting solution is heated at its reflux temperature for 18 hours, chilled, acidified and filtered to give 7 g of 4-quinolone-1-acetic acid having a m.p. 278°-279° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04119775 |
| Source dataset | uspto-grants-1978_10 |
| ORD ID | ord-8814bdfdad734bd9817417a991b3ebab |
| Source note | uspto-grants-1978_10 |