反应详情

To a solution of 5.0 g (0.017 mole) of 2-amino-4-(3-trifluoromethylphenylcarbamoylmethyl)thiazole in 22 ml of pyridine, there was added dropwise 2.8 g (0.03 mole) of methyl chloroformate. The solution was stirred and heated at 40°-45° for eighteen hours. The mixture was poured into 300 ml of cold water and stirring induced crystal formation. The solid was collected and the filter cake was washed with water. There was obtained 4.9 g of product, m.p. 137°-40°. N.M.R. (dimethyl-d6 sulfoxide) ∂ 3.6-3.9 (OCH3, CH2), 6.8 (hetero-aromatic), 7.3-8.1 (aromatic), 10.4 (HNC=O).

1. temperatureheated at 40°-45° for eighteen hours
2. stirringstirring induced crystal formation
3. customThe solid was collected
4. washthe filter cake was washed with water