Bromomethyl 4-methoxyphenyl ketone → 3-(p-Methoxy-phenacylmercapto)-4-n-butyl-1,2,4-triazole

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Reaction Steps

To a solution of 3-mercapto-4-n-butyl-1,2,4-triazole (10 g. or 0.063 mole) and sodium hydroxide (2.55 g. or 0.0637 mole) in 200 ml. of methanol was added α-bromo-p-methoxyacetophenone (15.3 g. or 0.067 mole). The reaction mixture was heated at reflux for 16 hours and the solvent removed in vacuum to leave a solid residue. The solid was washed with water and recrystallized from benzene-hexane to give 3-(p-methoxy-phenacylmercapto)-4-n-butyl-1,2,4-triazole melting at 79°-82° C. The structure was confirmed by its infrared and nuclear magnetic spectra.

Provenance & Evidence