Methyl iodide → Ethyl 3-methylamino-4-cyclohexylphenylglyoxylate

HRID 1112165Notes

Reaction equation

HRID 1112165 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([C:14](=[O:20])[C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH:5]=[CH:6][C:7]=1[CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1.[CH3:21]I>N1C=CC=CC=1>[CH3:21][NH:1][C:2]1[CH:3]=[C:4]([C:14](=[O:20])[C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH:5]=[CH:6][C:7]=1[CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 20515218Ethyl 3-amino-4-cyclohexylphenylglyoxylate

Product 1

HCID 20515175Ethyl 3-methylamino-4-cyclohexylphenylglyoxylate

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To a solution of 0.01 moles of ethyl 3-amino-4-cyclohexylphenylglyoxylate in 100 ml. of pyridine is added 0.1 moles of methyl iodide. The reaction mixture is stirred overnight at room temperature, filtered and concentrated. The residue is distilled to obtain ethyl 3-methylamino-4-cyclohexylphenylglyoxylate.

Workup

  1. filtrationfiltered
  2. concentrationconcentrated
  3. distillationThe residue is distilled

Sources & evidence

ORD record
ord-69c5d0bcd4c248feb0f9290ca11aa6bb
Source dataset
uspto-grants-1978_10
Patent number
US04120889

Reaction notes

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