反应详情

Five milliliters of thionyl chloride are added to a solution of 5.0 g (30 millimoles) tricyclo [4.3.1.12,5 ] undecane-1-ol in 30 ml dry anhydrous benzene and the entirety is refluxed for 1.5 hours. The reaction mixture is concentrated under reduced pressure and there is further added 20 ml of dry benzene. Reduced pressure concentration is repeated to distill out the excess thionyl chloride completely. The residue is distilled under reduced pressure to collect a fraction boiling at 95° C./3mmHg, to obtain 5.0 g (yield 89%) of 1-chlorotricyclo [4.3.1.12,5 ] undecane.

1. temperaturethe entirety is refluxed for 1.5 hours
2. concentrationThe reaction mixture is concentrated under reduced pressure and there
3. concentrationReduced pressure concentration
4. distillationto distill out the excess thionyl chloride completely
5. distillationThe residue is distilled under reduced pressure
6. customto collect a fraction boiling at 95° C./3mmHg