Benzoyl chloride → HCID 70624869, compound

HRID 1112203Notes

Reaction equation

HRID 1112203 reaction equation
[C:1]1([CH:7]2[C:16]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=3[CH2:10][CH:9]3[CH2:17][C:18](=O)[NH:19][CH2:20][CH2:21][N:8]23)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(Cl)(=O)C1C=CC=CC=1>>[C:1]1([CH:7]2[C:16]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=3[CH2:10][CH:9]3[CH2:17][CH2:18][NH:19][CH2:20][CH2:21][N:8]23)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 7412Benzoyl chlorideHCID 70625058HCID 70625058, compound

Product 1

HCID 70624869HCID 70624869, compound

Procedure

(7 RS,12aRS)-1,4,5,7,12,12a-hexahydro-7-phenyl-1,4-diazepino[1,7-b]isoquinolin-2(3H)-one [M.P. 232°-234°] was produced in analogous manner to Examples 1 (a) and (b) using benzoyl chloride instead of p-anisolyl chloride. Reduction analogous to Example 1 gave (7 RS,12aRS)-1,2,3,4,5,7,12,12a-octahydro-7-phenyl-1,4-diazepino[1,7-b]isoquinoline (M.P. of maleate 204°-205°).

Sources & evidence

ORD record
ord-3407a83e896141d392b7535d164473ae
Source dataset
uspto-grants-1978_10
Patent number
US04120965

Reaction notes

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