Water → HCID 70624778, compound

HRID 1112204Notes

Reaction equation

HRID 1112204 reaction equation
[C:1](Cl)(=[O:3])[CH3:2].[C:5]1([CH:11]2[C:20]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[CH2:14][CH:13]3[CH2:21][CH2:22][NH:23][CH2:24][CH2:25][N:12]23)[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.O>C(Cl)Cl>[C:1]([N:23]1[CH2:22][CH2:21][CH:13]2[N:12]([CH:11]([C:5]3[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=3)[C:20]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[CH2:14]2)[CH2:25][CH2:24]1)(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 962WaterHCID 6367Acetyl chlorideHCID 70624869HCID 70624869, compound

Product 1

HCID 70624778HCID 70624778, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

3.08 of acetyl chloride diluted with 10 ml of methylene chloride was added dropwise to a solution of 9.9 g (7 RS,12aRS)-1,2,3,4,5,7,12,12a-octahydro-7-phenyl-1,4-diazepino[1,7-b]isoquinoline in 100 ml of methylene chloride. The reaction mixture was stirred for 1 hour, then wasted twice with water, then dried with magnesium sulphate and concentrated to dryness to give (7RS,12aRS)-3-acetyl-1,2,3,4,5,7,12,12a-octahydro-7-phenyl-1,4-diazepino[1,7-b]isoquinoline (M.P. 145°-147°).

Workup

  1. dry with materialdried with magnesium sulphate
  2. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-bea7d362a5fe4942a209d98a66050c60
Source dataset
uspto-grants-1978_10
Patent number
US04120965

Reaction notes

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