Sodium Hydroxide → HCID 70625700, compound

Participants

Reaction Steps

A solution of 6.8 g of (7RS,12aRS)-1,2,3,4,5,7,12,12a-octahydro-7-phenyl-1,4-diazepino[1,7-b]isoquinoline-3-carboxylic acid ethyl ester in toluene was added dropwise slowly into a stirred and boiling mixture of 200 ml of toluene and 21.6 ml of 70% disodium (2-methoxyethoxy)aluminium hydride in benzene. The reaction mixture was refluxed for a further 30 minutes, and cooled to 0°. The complex and remaining reducing agent was decomposed by the slow dropwise addition of 60 ml of a 20% sodium hydroxide solution. The organic phase was separated off, washed with 100 ml of a 20% sodium hydroxide solution, then washed three times with water, then dried with magnesium sulphate, and finally concentrated to dryness to give the title compound (M.P. of maleate from methanol/ether 184°-186°).

Provenance & Evidence