Sodium Carbonate → S-[2-(5-Methyl-4-imidazolylmethylthio)ethyl]-N-cyano-N'-methylisothiourea

HRID 1112223Notes

Reaction equation

HRID 1112223 reaction equation
Cl.[CH3:2][C:3]1[NH:7][CH:6]=[N:5][C:4]=1[CH2:8][S:9][CH2:10][CH2:11][S:12][C:13](=[N:17][CH3:18])[NH:14][C:15]#[N:16].C(=O)([O-])[O-].[Na+].[Na+]>>[CH3:2][C:3]1[NH:7][CH:6]=[N:5][C:4]=1[CH2:8][S:9][CH2:10][CH2:11][S:12][C:13](=[N:17][CH3:18])[NH:14][C:15]#[N:16]

Participants

3

Reactant 2

HCID 10340Sodium CarbonateHCID 20387431S-[2-(5-methyl-4-imidazolylmethylthio)ethyl]-N-cyano-N'-methylisothiourea hydrochloride

Product 1

HCID 20387415S-[2-(5-Methyl-4-imidazolylmethylthio)ethyl]-N-cyano-N'-methylisothiourea

Procedure

This hydrochloride may be treated with aqueous sodium carbonate and the mixture extracted with chloroform and the chloroform extracts evaporated to give the free base.

Workup

  1. extractionthe mixture extracted with chloroform
  2. customthe chloroform extracts evaporated
  3. customto give the free base

Sources & evidence

ORD record
ord-ab9594230f544df3a55c302a987c182c
Source dataset
uspto-grants-1978_10
Patent number
US04120972

Reaction notes

Loading…