Potassium thiocyanate → HCID 20387432, compound

HRID 1112225Notes

Reaction equation

HRID 1112225 reaction equation
Cl.Cl[CH2:3][CH2:4][S:5][CH2:6][C:7]1[N:8]=[CH:9][NH:10][C:11]=1[CH3:12].[S-:13][C:14]#[N:15].[K+]>C(O)C>[CH3:12][C:11]1[NH:10][CH:9]=[N:8][C:7]=1[CH2:6][S:5][CH2:4][CH2:3][S:13][C:14]#[N:15]

Participants

4

Reactant 2

HCID 516872Potassium thiocyanateHCID 132173611-Chloro-2(5-methyl-4-imidazolylmethylthio)ethane hydrochloride

Product 1

HCID 20387432HCID 20387432, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1-Chloro-2-(5-methyl-4-imidazolylmethylthio)ethane hydrochloride (2.1 g) and potassium thiocyanate (0.97 g) were heated together under reflux in ethanol (50 ml) for 3 days. The mixture was evaporated to dryness and the residue was taken up in water, basified with sodium carbonate and extracted with chloroform. The chloroform extracts were dried (MgSO4) and evaporated to a residue which was recrystallised from acetonitrile to give 2-(5-methyl-4-imidazolylmethylthio)ethylthiocyanate m.p. 101°-103°.

Workup

  1. customThe mixture was evaporated to dryness
  2. extractionextracted with chloroform
  3. dry with materialThe chloroform extracts were dried (MgSO4)
  4. customevaporated to a residue which
  5. customwas recrystallised from acetonitrile

Sources & evidence

ORD record
ord-f5487bc3e1f94e9183d319abaa0876d8
Source dataset
uspto-grants-1978_10
Patent number
US04120972

Reaction notes

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