Cyanoacetamide → alpha-Cyano-beta-(2-Nitro-5-Fluorophenyl)Acrylamide

HRID 1112242ノート

反応式

HRID 1112242 の反応式
[F:1][C:2]1[CH:3]=[C:4]([C:7]([N+:10]([O-:12])=[O:11])=[CH:8][CH:9]=1)[CH:5]=O.[C:13]([CH2:15][C:16]([NH2:18])=[O:17])#[N:14].N1CCCCC1>C(O)C>[C:13]([C:15](=[CH:5][C:4]1[CH:3]=[C:2]([F:1])[CH:9]=[CH:8][C:7]=1[N+:10]([O-:12])=[O:11])[C:16]([NH2:18])=[O:17])#[N:14]

参加物

5

反応物 3

HCID 7898CyanoacetamideHCID 8082PiperidineHCID 5870905-Fluoro-2-nitrobenzaldehyde

生成物 1

HCID 53864188alpha-Cyano-beta-(2-Nitro-5-Fluorophenyl)Acrylamide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 3-fluoro-6-nitrobenzaldehyde (10.0 g., 0.0592 mole), 2-cyanoacetamide (5.24 g., 0.0622 mole), piperidine (0.37 g., 4.36 millimole) and ethanol (92 ml.) is heated to reflux on a steam bath for 2 hours. It is then cooled in an ice-bath whereupon the product precipitates and is recovered by filtration, washed with cold ethanol and dried. Yield = 9.1 g. (65%) of crude product. M.P. 162°-166° C.

後処理

  1. temperatureis heated
  2. temperatureto reflux on a steam bath for 2 hours
  3. temperatureIt is then cooled in an ice-bath whereupon the product
  4. customprecipitates
  5. filtrationis recovered by filtration
  6. washwashed with cold ethanol
  7. customdried

出典と根拠

ORDレコード
ord-2978c5c8d47b466e8e1317ca553d243f
出典データセット
uspto-grants-1978_10
特許番号
US04120962

反応ノート

読み込み中…