Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Bromine → Methyl 5-bromo-3-phenylbenzo[b]thiophene-2-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Bromine | HCID 24408 | — |
| 반응물 | 3-Phenylbenzo[b]thiophene-2-carboxylic acid methyl ester | HCID 22763504 | — |
| 반응물 | Sodium Bisulfite | HCID 23665763 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | Methyl 5-bromo-3-phenylbenzo[b]thiophene-2-carboxylate | HCID 22763497 | — |
반응 단계
Add 29.3 g. bromine (10 ml; 0.37 mole) to 8.0 g. (0.03 mole) of methyl 3-phenylbenzo[b]thiophene-2-carboxylate in 100 ml of acetic acid and stir the mixture overnight at room temperature. Add a saturated solution of sodium bisulfite. Decant the supernatant and wash the oil with water. Triturate with methanol. Recrystallize from methanol to yield the title compound; m.p. 125°-126°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04122034 |
| 출처 데이터셋 | uspto-grants-1978_10 |
| ORD ID | ord-11e4011c36b34106a188ddf2cc8c06fc |
| 출처 메모 | uspto-grants-1978_10 |