HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-Bromo-3-phenylbenzo[b]thiophene-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methyl 5-bromo-3-phenylbenzo[b]thiophene-2-carboxylate | HCID 22763497 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | 5-Bromo-3-phenylbenzo[b]thiophene-2-carboxylic acid | HCID 22763468 | — |
Reaction Steps
Heat three grams of methyl 5-bromo-3-phenylbenzo[b]thiophene-2-carboxylate in a mixture of 50 ml of methanol and 30 ml of 10% sodium hydroxide, under reflux for 1 hour. Add concentrated hydrochloric acid to yield the title compound as a precipitate. Recrystallize from benzene; m.p. 265°-266°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04122034 |
| Source dataset | uspto-grants-1978_10 |
| ORD ID | ord-d677a14a9a5e40c6bdb194f4df9a72be |
| Source note | uspto-grants-1978_10 |