Sodium Hydroxide → HCID 12893604, compound

HRID 1112305Notes

Reaction equation

HRID 1112305 reaction equation
C([N:4]1[CH2:19][CH2:18][C:7]2[N:8]3[C:12]4[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=4[N:10]=[C:9]3[S:17][C:6]=2[CH2:5]1)(=O)C.[OH-].[Na+]>C(O)C>[CH2:5]1[C:6]2[S:17][C:9]3[N:8]([C:7]=2[CH2:18][CH2:19][NH:4]1)[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[N:10]=3

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 12893613HCID 12893613, compound

Product 1

HCID 12893604HCID 12893604, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-Acetyl-1,2,3,4-tetrahydropyrido[4',3':4,5]thiazolo[3,2-a]benzimidazole (13.5 g., 0.05 mole) is dissolved in 100 ml. of absolute ethanol. Sodium hydroxide (3 ml. of 50% aqueous sodium hydroxide) is added and the reaction mixture is digested on the steam cone for one hour. It is then concentrated in vacuo and the residue is washed with water. The white crystalline material is filtered and dried to yield 7.3 g. of 1,2,3,4-tetrahydropyrido[4',3':4,5]thiazolo[3,2-a]benzimidazole, which is recrystallized from methanol-chloroform to yield 4.3 g. of analytical sample, m.p. 238°-243°.

Workup

  1. concentrationIt is then concentrated in vacuo
  2. washthe residue is washed with water
  3. filtrationThe white crystalline material is filtered
  4. customdried
  5. customto yield 7.3 g
  6. customof 1,2,3,4-tetrahydropyrido[4',3':4,5]thiazolo[3,2-a]benzimidazole, which is recrystallized from methanol-chloroform
  7. customto yield 4.3 g

Sources & evidence

ORD record
ord-9c2a872633244a8bacf16d33aab8dc45
Source dataset
uspto-grants-1978_10
Patent number
US04122083

Reaction notes

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