Pyridine → Methyl N-[(benzyloxy)carbonyl]-L-valinate

Participants

Reaction Steps

5.61 g of the resin 6a obtained according to Instruction (5b) are stirred in 40 ml of chloroform with 0.50 ml of pyridine and 0.350g of L-valine methyl ester hydrochloride for 130 minutes. The resin is filtered off and washed with 200 ml of chloroform and the filtrate is worked up as described in the previous Example. The yield is 0.300 g of Z-Val-Val-OMe and the melting point of the crude product is 120° C.; according to the IR and NMR spectrum, this product is identical to the authentic comparative preparation.

Provenance & Evidence