HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1112335Generated: November 2, 2026
Hydrochloric Acid → HCID 131711302, compound
https://huagongshe.com/reaction/1112335
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)- | HCID 85083 | — |
| Reactant | Alanylphenylalanine methyl ester | HCID 12988705 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 131711302 | HCID 131711302 | — |
Reaction Steps
447 mg of triethylamine are added to a mixture of 488 mg of Ala-Phe-OMe. HCl D 2 and 845 mg of Boc-Pro≈SO2 in 20 ml of absolute tetrahydrofuran, whereupon the color of the mixture becomes deep red. The mixture is stirred for 1 hour at 20° C. The pale yellow mixture is then worked up as described in Example D 1 and the product is digested with petroleum ether.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04122090 |
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| Source dataset | uspto-grants-1978_10 |
|---|
| ORD ID | ord-adb1123f37624eada19f7ab868dc34fe |
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| Source note | uspto-grants-1978_10 |
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