Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)- | HCID 85083 | — |
| Reactant | HCID 131711309 | HCID 131711309 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 131711308 | HCID 131711308 | — |
Reaction Steps
552 mg of triethylamine are added to a mixture of 965 mg of Pro-Phe-Phe-OMe.HCl D 12 and 1,044 mg of Boc-Pro≈SO2 in 20 ml of absolute tetrahydrofuran, whereupon the mixture develops a deep red coloration. It is stirred for 1.5 hours at 20° C. The pale yellow mixture is then worked up as described in Example D 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04122090 |
|---|
| Source dataset | uspto-grants-1978_10 |
|---|
| ORD ID | ord-d29d282af6494944ad36bfbec5bee4f0 |
|---|
| Source note | uspto-grants-1978_10 |
|---|
