Acetic Anhydride → HCID 22763844, compound

Participants

Reaction Steps

A mixture of 2.28 g. of 4-(1-isoquinolyl)-piperidin-4-ol, 1 ml. of pyridine, 1 ml. of acetic anhydride and 20 ml. of benzene is stirred for 3 hours at 25°. The crude 1-acetyl-4-(1-isoquinolyl)-piperidin-4-ol obtained after the customary work up is heated under reflux with 0.7 g. of LiAlH4 in 40 ml. of THF for 24 hours, under nitrogen. The mixture is worked up with sodium hydroxide solution and chloroform in the customary manner to give 1-ethyl-4-(1-isoquinolyl)-piperidin-4-ol, m.p. 275°-276°.

Provenance & Evidence