HRID1112366

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2244

Aspirin

C9H8O4

结构：CC[C@]12CCCN3CCc4c(n(c5ccccc45)[C@@](O)(C(=O)OC)C1)[C@@H]32

HCID15376

Vincamine

C21H26N2O3

PRODUCTS

生成物

结构：CC(=O)Oc1ccccc1C(=O)[O-].CC[C@]12CCCN3CCc4c(n(c5ccccc45)[C@@](O)(C(=O)OC)C1)[C@@H]32

HCID86736089

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

2 次

溶剂HCID6212

Chloroform

CHCl3

CONDITIONS

反应条件

温度: 70 °C

PROCEDURE

实验过程

A solution of 3.6 g (2.10-` moles) of acetylsalicylic acid in 30 mls of ethanol is added to a solution of 7.08 g (2.10-2 moles) of vincamine in 80 mls of ethanol and 60 mls of CHCl3. The mixture is maintained under stirring at 70° C. for 10 minutes and then concentrated to 60 mls. The residue is taken with ethanol (70 mls) and the solvent is evaporated to a final volume of 15 mls.

WORKUP

后处理

temperatureThe mixture is maintained
concentrationconcentrated to 60 mls
customthe solvent is evaporated to a final volume of 15 mls

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-58e56f3178c24e31977211f621595d8e
来源数据集: uspto-grants-1978_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04122179
来源说明: uspto-grants-1978_10

反应 SMILES

[C:1]([O:4][C:5]1[C:6](=[CH:10][CH:11]=[CH:12][CH:13]=1)[C:7]([OH:9])=[O:8])(=[O:3])[CH3:2].[CH3:14][CH2:15][C@:16]12[CH2:32][C@:31]([OH:37])([C:33]([O:35][CH3:36])=[O:34])[N:30]3[C:22]4=[C:23]([CH2:38][CH2:39][N:20]([C@@H:21]14)[CH2:19][CH2:18][CH2:17]2)[C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][C:29]=13>C(O)C.C(Cl)(Cl)Cl>[CH3:14][CH2:15][C@:16]12[CH2:32][C@:31]([OH:37])([C:33]([O:35][CH3:36])=[O:34])[N:30]3[C:22]4=[C:23]([CH2:38][CH2:39][N:20]([C@@H:21]14)[CH2:19][CH2:18][CH2:17]2)[C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][C:29]=13.[C:1]([O:4][C:5]1[C:6](=[CH:10][CH:11]=[CH:12][CH:13]=1)[C:7]([O-:9])=[O:8])(=[O:3])[CH3:2]