Dimethyl Sulfate → Vincamine methylsulfate

Participants

Reaction Steps

7.08 g (2.10-2 moles) of vincamine are dissolved in 900 mls of boiling anhydrous acetone. Under stirring, 1.8 mls of dimethylsulfate are added and the resulting mixture is maintained under boiling for 6 hours. The mixture is concentrated to 400 mls and maintained on standing for a night. The mixture is filtered, washed onto the filter with ether and dried in a vacuum furnace at 50° C. There are obtained 7 g of a product having melting point of 191° C., soluble in water and alcohol.

Provenance & Evidence