1-Pyrrolidineethanamine → 63207-76-1

HRID 1112405Notes

Reaction equation

HRID 1112405 reaction equation
[C:1]1([CH:7]([CH2:11][CH3:12])[C:8]([Cl:10])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[N:13]1([CH2:18][CH2:19][NH2:20])[CH2:17][CH2:16][CH2:15][CH2:14]1>C1C=CC=CC=1>[ClH:10].[N:13]1([CH2:18][CH2:19][NH:20][C:8](=[O:9])[CH:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH2:11][CH3:12])[CH2:17][CH2:16][CH2:15][CH2:14]1

Participants

4

Reactant 2

HCID 13441-PyrrolidineethanamineHCID 981732-Phenylbutyryl chloride

Product 1

HCID 304730863207-76-1

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent2×

Procedure

To a solution of 1 mol of α-phenyl-α-ethyl acetyl chloride in 2 liters of benzene add, with agitation, a benzene solution of 1 mol of 2-pyrrolidino -ethyl amine. The hydrochloric acid formed during condensation attaches itself to the pyrrolidine group and the expected derivative crystallizes out in the reaction medium.

Sources & evidence

ORD record
ord-129d389876c44e63aec4bd8f90c3fb8f
Source dataset
uspto-grants-1978_10
Patent number
US04122199

Reaction notes

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