Dimethylformamide → Oxalic acid--1-[4-(benzenesulfonyl)-4-phenylbutyl]-4-phenylpiperazine (1/1)

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Reaction Steps

A mixture of 6.16 g of 1-chloro-4-phenyl-4-phenylsulfonylbutane, 4.25 g of 1-phenylpiperazine, 3.5 of sodium carbonate and 80 ml of dimethylformamide was refluxed with stirring for 23 hours. After cooling, water was added to the reaction mixture. The resulting mixture was extracted with chloroform, and the extract was washed with a 10% aqueous hydrochloric acid solution and with an aqueous potassium carbonate solution. To the organic layer was added 1.8 g of oxalic acid. The resulting oxalate was purified with 60% ethanol to give 6 g of 1-(4-phenyl-4-phenylsulfonylbutyl)-4-phenylpiperazine oxalate as white crystals, melting at 179°-181° C with decomposition.

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