HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → 2-[3-(1-Piperidinyl)propoxy]benzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Salicylaldehyde | HCID 6998 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Piperidine, 1-(3-chloropropyl)- | HCID 79625 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-[3-(1-Piperidinyl)propoxy]benzaldehyde | HCID 13795259 | — |
Reaction Steps
Salicylaldehyde (27g) is treated first with 11g of 50% sodium hydride in 175ml of dimethylformamide and then with 150ml of a 2N toluene solution of N-(3-chloropropyl)piperidine following the procedure described in Example 31A, yielding 47.7g of the title compound as an oil, boiling point 155°-160° C at 0.2-0.3mm of Hg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04122255 |
| Source dataset | uspto-grants-1978_10 |
| ORD ID | ord-928139334ffd4fd081eacb43ecc8107b |
| Source note | uspto-grants-1978_10 |