HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1112456Generated: November 3, 2026
7-Amino-3-methyl-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid → HCID 86736112, compound
https://huagongshe.com/reaction/1112456
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 7-Amino-3-methyl-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid | HCID 1883 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Isobutyl chloroformate | HCID 62365 | — |
| Reactant | (2-Formyl-1H-pyrrol-1-yl)acetic acid | HCID 12459347 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 86736112 | HCID 86736112 | — |
Reaction Steps
A solution of (2-formyl-1-pyrryl)acetic acid (0.02 m) and triethylamine (0.02 m) in tetrahydrofuran (THF) is cooled to 0° C. While stirring, isobutyl chloroformate (0.02 m) is added and the temperature is maintained at 0° C for 15 minutes. A cold solution of 7-amino-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (0.02 m) and triethylamine (0.02 m) in 50% aqueous THF is added to the previous solution with stirring.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04122260 |
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| Source dataset | uspto-grants-1978_10 |
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| ORD ID | ord-b88a614bd8764c49bdca59c4243baa44 |
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| Source note | uspto-grants-1978_10 |
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