Ethyl 2-cyano-3-(5-methyl-2-pyridylamino)acrylate → HCID 178423346, compound

HRID 1112523Notes

Reaction equation

HRID 1112523 reaction equation
[NH:1]1[C:5]([C:6]2[C:11](=[O:12])[N:10]3[CH:13]=[CH:14][CH:15]=[CH:16][C:9]3=[N:8][CH:7]=2)=[N:4][N:3]=[N:2]1.[C:17](C(=CNC1C=CC(C)=CN=1)C(OCC)=O)#N>>[CH3:17][C:14]1[CH:15]=[CH:16][C:9]2[N:10]([CH:13]=1)[C:11](=[O:12])[C:6]([C:5]1[NH:1][N:2]=[N:3][N:4]=1)=[CH:7][N:8]=2

Participants

3

Reactant 2

HCID 4480416Ethyl 2-cyano-3-(5-methyl-2-pyridylamino)acrylateHCID 178515422HCID 178515422, compound

Product 1

HCID 178423346HCID 178423346, compound

Procedure

In a manner similar to that described for the preparation of 3-(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one in Example 2, the title compound was prepared from ethyl 2-cyano-3-(5-methyl-2-pyridylamino)acrylate. The product (42.8% yield) had m.p. 321°-322° (decomp) after recrystallization from glacial acetic acid.

Sources & evidence

ORD record
ord-45e45fa6b4be419a937bcec8636cfc49
Source dataset
uspto-grants-1978_10
Patent number
US04122274

Reaction notes

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