HCID 3826679, compound → 4H-Pyrido[1,2-a]pyrimidin-4-one, 8-methyl-3-(1H-tetrazol-5-yl)-

HRID 1112524Notes

Reaction equation

HRID 1112524 reaction equation
[C:1]([C:3](=[CH:9][NH:10][C:11]1[CH:16]=[C:15]([CH3:17])[CH:14]=[CH:13][N:12]=1)[C:4](OCC)=[O:5])#[N:2].[NH:18]1C(C2C(=O)N3C=CC=CC3=NC=2)=N[N:20]=[N:19]1>>[CH3:17][C:15]1[CH:14]=[CH:13][N:12]2[C:4](=[O:5])[C:3]([C:1]3[NH:2][N:20]=[N:19][N:18]=3)=[CH:9][N:10]=[C:11]2[CH:16]=1

Participants

3

Reactant 2

HCID 3826679HCID 3826679, compoundHCID 178515422HCID 178515422, compound

Product 1

HCID 1784280844H-Pyrido[1,2-a]pyrimidin-4-one, 8-methyl-3-(1H-tetrazol-5-yl)-Yield 16%

Procedure

The title compound (16% yield, m.p. 307° with decomposition) was prepared from ethyl 2-cyano-3-(4-methyl-2-pyridylamino)acrylate in a manner similar to that described for the preparation of 3-(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]-pyrimidin-4-one in Example 2.

Sources & evidence

ORD record
ord-a3389919037e4160a1e5ad0effab0082
Source dataset
uspto-grants-1978_10
Patent number
US04122274

Reaction notes

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