Ethyl 2-cyano-3-(5-phenyl-2-pyridylamino)acrylate → HCID 178515420, compound

HRID 1112527Notes

Reaction equation

HRID 1112527 reaction equation
[CH2:1]([C:5]1[CH:6]=[CH:7][C:8]2[N:9]([CH:20]=1)[C:10](=[O:19])[C:11]([C:14]1[NH:18][N:17]=[N:16][N:15]=1)=[CH:12][N:13]=2)[CH2:2][CH2:3][CH3:4].[C:21]([C:23](=CNC1C=CC(C2C=CC=CC=2)=CN=1)C(OCC)=O)#N>>[C:1]1([C:5]2[CH:6]=[CH:7][C:8]3[N:9]([CH:20]=2)[C:10](=[O:19])[C:11]([C:14]2[NH:15][N:16]=[N:17][N:18]=2)=[CH:12][N:13]=3)[CH:23]=[CH:21][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 70592147Ethyl 2-cyano-3-(5-phenyl-2-pyridylamino)acrylateHCID 178440676HCID 178440676, compound

Product 1

HCID 178515420HCID 178515420, compoundYield 31%

Procedure

In a manner similar to that described for the preparation of 7-n-butyl-3-(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one in Example 7, the title compound (m.p. 308°-309° decomp) was prepared in 31% yield from ethyl 2-cyano-3-(5-phenyl-2-pyridylamino)acrylate.

Sources & evidence

ORD record
ord-e627a8c30c8048b887bc87c1043523f7
Source dataset
uspto-grants-1978_10
Patent number
US04122274

Reaction notes

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