2(5H)-Thiazolone, 4-amino- → HCID 178509023, compound

HRID 1112533Notes

Reaction equation

HRID 1112533 reaction equation
[NH:1]=[C:2]1[CH2:6][S:5][C:4](=[O:7])[NH:3]1.[NH:8]=[C:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11](=N)[NH:10]1>CO>[NH:8]=[C:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11](=[C:6]2[S:5][C:4](=[O:7])[NH:3][C:2]2=[NH:1])[NH:10]1

Participants

4

Reactant 2

HCID 1373471612(5H)-Thiazolone, 4-amino-HCID 178508669HCID 178508669, compound

Product 1

HCID 178509023HCID 178509023, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 3.5 parts of 4-imino-2-thiazolidinone, 4.4 parts of 1,3-diiminoisoindoline and 100 parts of methanol was stirred under an atmosphere of nitrogen at room temperature for 3 hours and then at reflux temperature for 2 hours. The reaction mixture was cooled to 25° C. and the solid therein was collected by filtration, washed with fresh methanol and dried in vacuo at 50° C. to obtain 5.4 parts of 1-imino-3-(2-oxo-4-imino-5-thiazolidinylidene)isoindoline as a yellow powder melting at 346°-348° C. (dec).

Workup

  1. temperatureat reflux temperature for 2 hours
  2. temperatureThe reaction mixture was cooled to 25° C.
  3. filtrationthe solid therein was collected by filtration
  4. washwashed with fresh methanol
  5. customdried in vacuo at 50° C.

Sources & evidence

ORD record
ord-14495fd1364f425cb1a05408538b3935
Source dataset
uspto-grants-1978_10
Patent number
US04122261

Reaction notes

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