Propionic Acid → Dimethyl (3,3-dimethyl-2-oxo-4-phenylbutyl)phosphonate

HRID 1112550Notes

Reaction equation

HRID 1112550 reaction equation
[C:1](O)(=O)C(C)C.C(O)(=O)CC.[CH3:12][CH:13]([CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[C:14](=[O:22])[CH2:15][P:16](=[O:21])([O:19][CH3:20])[O:17][CH3:18].C(Cl)C1C=CC=CC=1>>[CH3:12][C:13]([CH3:1])([CH2:23][C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1)[C:14](=[O:22])[CH2:15][P:16](=[O:21])([O:19][CH3:20])[O:17][CH3:18]

Participants

5

Reactant 4

HCID 1032Propionic Acid2×HCID 6590Isobutyric AcidHCID 7503Benzyl ChlorideHCID 20082134Dimethyl 3-methyl-2-oxo-4-phenylbutylphosphonate

Product 1

HCID 14302191Dimethyl (3,3-dimethyl-2-oxo-4-phenylbutyl)phosphonate

Procedure

Further, following the procedure of Preparation 1, but using in place of the isobutyric acid of Preparation 1, part A, propionic acid, there is prepared dimethyl 3-methyl-2-oxo-4-phenylbutylphosphonate. Following the procedure of Preparation 1, but using the substituted benzyl chlorides described above in place of benzyl chloride and propionic acid in place of isobutyric acid there are prepared the various dimethyl 3-methyl-2-oxo-4-(substituted phenyl)-butylphosphonates wherein the phenyl substitution is as described above.

Workup

  1. customthe procedure of Preparation 1
  2. customthe procedure of Preparation 1

Sources & evidence

ORD record
ord-ee80e715f6424a898fe58ecae6fcc2f4
Source dataset
uspto-grants-1978_10
Patent number
US04122282

Reaction notes

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