2-Pentanamine → N-(1-methylbutyl)-4-(methylsulfonyl)-2,6-dinitro-m-toluidine

HRID 1112567ノート

反応式

HRID 1112567 の反応式
Cl[C:2]1[C:3]([N+:16]([O-:18])=[O:17])=[C:4]([CH3:15])[C:5]([S:11]([CH3:14])(=[O:13])=[O:12])=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].[NH2:19][CH:20]([CH2:22][CH2:23][CH3:24])[CH3:21]>C1C=CC=CC=1>[CH3:21][CH:20]([NH:19][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][C:5]([S:11]([CH3:14])(=[O:13])=[O:12])=[C:4]([CH3:15])[C:3]=1[N+:16]([O-:18])=[O:17])[CH2:22][CH2:23][CH3:24]

参加物

4

反応物 2

HCID 122462-PentanamineHCID 233359733-Chloro-6-(methylsulfonyl)-2,4-dinitrotoluene

生成物 1

HCID 23335968N-(1-methylbutyl)-4-(methylsulfonyl)-2,6-dinitro-m-toluidine

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

A mixture of 3-chloro-6-(methylsulfonyl)-2,4-dinitrotoluene (10.0 g., 0.034 mole) and 2-aminopentane (6.1 g. 0.07 mole) is refluxed in benzene (75 ml.) for 4 hours. After standing overnight, the mixture is successively washed with dilute hydrochloric acid, water, a 5% aqueous potassium carbonate solution and finally water. The mixture is then dried over magnesium sulfate. Removal of the magnesium sulfate and solvent leaves the desired product as a yellow oil which readily crystallized on cooling. The crude product is recrystallized from ethanol to give 9.5 grams with m.p. 85°-88° C.

後処理

  1. washthe mixture is successively washed with dilute hydrochloric acid, water
  2. dry with materialThe mixture is then dried over magnesium sulfate
  3. customRemoval of the magnesium sulfate and solvent

出典と根拠

ORDレコード
ord-3a363d62cbe544d189218a9cc54c6667
出典データセット
uspto-grants-1978_10
特許番号
US04123250

反応ノート

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