Water → HCID 21333356, compound

HRID 1112595Notes

Reaction equation

HRID 1112595 reaction equation
[C:1]1([C:7]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:8]2[CH:9]=[CH:10][C:11]([C:14]#[N:15])=[N:12][CH:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH2:28].[OH-].[K+]>CO>[C:16]1([C:7]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[C:8]2[CH:9]=[CH:10][C:11]([C:14]([NH2:15])=[O:28])=[N:12][CH:13]=2)[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

Participants

5

Reactant 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 21333323HCID 21333323, compound

Product 1

HCID 21333356HCID 21333356, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Dissolve 5 g. of 5-(triphenylmethyl)-2-cyanopyridine in a mixture consisting of 50 ml. of water and 1.0 liter of methanol. Add 4 g. of potassium hydroxide and heat the mixture at reflux for 15 hours. Remove the methanol under reduced pressure, triturate the residue with water and dry the solids obtained thereby. Crystallize the product from acetonitrile to obtain the product of this example. m.p. 239°-240° C.

Workup

  1. dissolutionDissolve 5 g
  2. additionAdd 4 g
  3. temperatureat reflux for 15 hours
  4. customRemove the methanol under reduced pressure
  5. customtriturate the residue with water
  6. customdry the solids
  7. customobtained
  8. customCrystallize the product from acetonitrile
  9. customto obtain the product of this example

Sources & evidence

ORD record
ord-214f2c609b6048e491c9eee8a5dcfe5f
Source dataset
uspto-grants-1978_10
Patent number
US04123433

Reaction notes

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