HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroform → (-)-2-Phenoxypropyl tosylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroform | HCID 6212 | — |
| Reactant | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| Reactant | 2-Phenoxy-1-propanol | HCID 20129 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | (-)-2-Phenoxypropyl tosylate | HCID 22762443 | — |
Reaction Steps
(-)-2-Phenoxypropanol [α]D25 = -38.95° (c. 0.9, CHCl3) was treated with tosylchloride in pyridine to give the corresponding (-)-2-phenoxypropyl tosylate of which 1.10 g. was reacted with LiPPh2 following Example 28 to give 0.87 g. of (+)-2-phenoxypropyl diphenylphosphine having [α]D25 = +27.90° (c. 3.03, CHCl3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04123465 |
| Source dataset | uspto-grants-1978_10 |
| ORD ID | ord-b314cc77bdb546f283452703c473f565 |
| Source note | uspto-grants-1978_10 |