Hydrochloric Acid → HCID 22762736, compound

Participants

Reaction Steps

To a solution of 2-iodo-4-aminomethyl-6-(1,1-dimethylethyl)-3-pyridinol (4.8 g., 0.016 mole) in ethanol (50 ml.) is added 12N hydrochloric acid (3 ml.). The resulting solution is diluted slowly with ether (150 ml.) and cooled to 0°-5° C. whereupon a solid is deposited. The solid is collected, washed with ether and air-dried to give 2-iodo-4-aminomethyl-6-(1,1-dimethylethyl)-3-pyridinol dihydrochloride (5.4 g., 91%), m.p. 177°-179° C. with dec. Recrystallization from ether-ethanol-water (125:50:2; v:v:v) affords an analytical sample of the 2-iodo-4-aminomethyl-6-(1,1-dimethylethyl)-3-pyridinol dihydrochloride as colorless needles, m.p. 178°-179° C. with dec.

Provenance & Evidence