Acetic Acid → HCID 22762665, compound

HRID 1112736Notes

Reaction equation

HRID 1112736 reaction equation
[C:1]1([C:7]2[O:11][C:10]([CH2:12][N:13]3[CH2:18][CH2:17][N:16]([C:19]4[CH:24]=[CH:23][C:22]([NH2:25])=[CH:21][CH:20]=4)[CH2:15][CH2:14]3)=[N:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:26](O)(=[O:28])[CH3:27].C(OC(=O)C)(=O)C>O>[C:1]1([C:7]2[O:11][C:10]([CH2:12][N:13]3[CH2:14][CH2:15][N:16]([C:19]4[CH:20]=[CH:21][C:22]([NH:25][C:26](=[O:28])[CH3:27])=[CH:23][CH:24]=4)[CH2:17][CH2:18]3)=[N:9][CH:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 7918Acetic AnhydrideHCID 22762560HCID 22762560, compound

Product 1

HCID 22762665HCID 22762665, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The 4-aminophenyl compound of Example 36 (3.0 g; 0.009 mole) was warmed on a steam bath with glacial acetic acid (5 ml) and acetic anhydride (10 ml) for 1 hour. The mixture was poured into water (200 ml), stirred well and the collected precipitate washed with water and dried. After recrystallisation from methanol the product weighed 2.45 g and melted at 196°-7° C.

Workup

  1. washthe collected precipitate washed with water
  2. customdried
  3. customAfter recrystallisation from methanol the product

Sources & evidence

ORD record
ord-81da04f019d34b54bef460fe7aecf8fd
Source dataset
uspto-grants-1978_10
Patent number
US04123529

Reaction notes

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