HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Amino-1-propanol → [2-(3-Hydroxypropyl)amino-2-oxoethoxy]acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Amino-1-propanol | HCID 9086 | — |
| Reactant | 1,4-Dioxane-2,6-dione | HCID 78232 | — |
| Reactant | Methanesulfonate | HCID 85257 | — |
| Product | [2-(3-Hydroxypropyl)amino-2-oxoethoxy]acetic acid | HCID 20558885 | — |
Reaction Steps
methanesulfonate by (a) reacting diglycolic anhydride and 3-aminopropanol to produce [2-(3-hydroxypropyl)amino-2-oxoethoxy]acetic acid, (b) heating to cyclize the latter to obtain 4-(3-hydroxypropyl)-3,5-dioxomorpholine, (c) esterifying the latter with methanesulfonyl chloride to produce 3-(3,5-dioxomorpholino)propyl methanesulfonate and (d) reacting the mesylate with 4-[bis(2-bromo-p-tolyl)methyl]piperidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04123538 |
| Source dataset | uspto-grants-1978_10 |
| ORD ID | ord-724478cfc6014bf5bc8d3769098d3765 |
| Source note | uspto-grants-1978_10 |