HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Toluenesulfonyl chloride → HCID 88726054, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 10-Methoxy-1,6-dimethylergoline-8beta-methanol | HCID 9796365 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 88726054 | HCID 88726054 | 72.7% |
Reaction Steps
A mixture of 10 g of 10-methoxy-1,6-dimethylergoline-8β-methanol, 12.4 ml of triethylamine, and 12.6 g of tosyl chloride in 200 ml of methylene chloride is refluxed 5 hr. The solution is washed first with 10% Na2CO3 and then with water, the solvent is evaporated in vacuo, and the residue is crystallized from methanol to give 11 g of 10-methoxy-1,6-dimethylergoline-8β-methanol tosylate; m.p. 169° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04123613 |
| Source dataset | uspto-grants-1978_10 |
| ORD ID | ord-efe6e5a450324c3e8107528b0c513bbb |
| Source note | uspto-grants-1978_10 |