Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Marcellomycin | HCID 107861 | — |
| Reactant | Methyl 2-ethyl-5,7,10-trihydroxy-6,11-dioxo-6,11-dihydrotetracene-1-carboxylate | HCID 120369 | — |
| Reactant | Musettamycin | HCID 44559595 | — |
| Reactant | HCID 44584031 | HCID 44584031 | — |
| Product | HCID 86736131 | HCID 86736131 | — |
Reaction Steps
The solids obtained were chromatographed on Brinkmann 60F254 silica gel thin layer plates using an 80:20 toluene:methanol solvent system. The first band to elute was shown by thin layer chromatography to be a complex inactive mixture. The second band gave a characteristic pinkish red zone at about Rf =0.75. This fraction was also inactive and was found to comprise mainly η-pyrromycinone. The third fraction to elute gave a single zone with Rf ~0.3. This was determined to be musettamycin and was highly active when tested on both the L1210 and P388 mouse leukemia systems. The final band to elute gave a zone of Rf ~0.3 and comprised mainly marcellomycin but also a minor proportion of rudolphomycin. This component exhibited high activity when tested on L1210 and P388 mouse leukemia systems.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04123608 |
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| Source dataset | uspto-grants-1978_10 |
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| ORD ID | ord-cf40423c1ac848c3b91a7b3118efcbce |
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| Source note | uspto-grants-1978_10 |
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