3-Pyridinecarboxylic acid, 4-(trifluoromethyl)- → N-(3-{2-[2-(3-Chloro-4-hydroxy-phenyl)-ethylamino]pyrimidin-4-yl}-benzyl)-N-isopropyl-4-trifluoromethyl-nicotinamide

HRID 1113472Notes

Reaction equation

HRID 1113472 reaction equation
[Cl:1][c:2]1[c:3]([OH:28])[cH:4][cH:5][c:6]([CH2:8][CH2:9][NH:10][c:11]2[n:12][cH:13][cH:14][c:15](-[c:17]3[cH:18][c:19]([CH2:23][NH:24][CH:25]([CH3:26])[CH3:27])[cH:20][cH:21][cH:22]3)[n:16]2)[cH:7]1.[F:29][C:30]([c:31]1[cH:32][cH:33][n:34][cH:35][c:36]1[C:37](=[O:38])[OH:39])([F:40])[F:41]>>[Cl:1][c:2]1[c:3]([OH:28])[cH:4][cH:5][c:6]([CH2:8][CH2:9][NH:10][c:11]2[n:12][cH:13][cH:14][c:15](-[c:17]3[cH:18][c:19]([CH2:23][N:24]([CH:25]([CH3:26])[CH3:27])[C:37]([c:36]4[c:31]([C:30]([F:29])([F:40])[F:41])[cH:32][cH:33][n:34][cH:35]4)=[O:38])[cH:20][cH:21][cH:22]3)[n:16]2)[cH:7]1

Participants

3

Reactant 2

HCID 27775493-Pyridinecarboxylic acid, 4-(trifluoromethyl)-HCID 586034412-Chloro-4-(2-{4-[3-(isopropylamino-methyl)-phenyl]-pyrimidin-2-ylamino}-ethyl)-phenol

Product 1

HCID 58603776N-(3-{2-[2-(3-Chloro-4-hydroxy-phenyl)-ethylamino]pyrimidin-4-yl}-benzyl)-N-isopropyl-4-trifluoromethyl-nicotinamide

Sources & evidence

ORD record
ord-fff6e7f127084a9683f912232cb9417b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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