Dimethylamine → HCID 21980634, compound

Participants

Role	Name	HCID	Charge
Reactant	Dimethylamine	HCID 674	—
Reactant	Benzyl 9-methoxy-1,3-dioxo-1,2,3,6-tetrahydropyrrolo[3,4-c]carbazole-4-carboxylate	HCID 11843434	—
Reactant	4-(2-Chlorophenyl)-8-(4-iodobutyl)-9-methoxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	HCID 21980906	—
Product	HCID 21980634	HCID 21980634	64%

Reaction Steps

Reaction of the iodide (173) prepared as described in example 312 with aqueous dimethylamine using the procedure described in example 179 of Scheme 3 except that the reaction conditions were 6 h at room temperature gave (174) (64%) as an orange powder, mp 162–164° C. 1H NMR δ [(CD3)2SO] 11.85 (s, 1H), 11.04 (br s, 1H), 8.42 (s, 1H), 7.57 (dd, J=8.0, 2.2 Hz, 1H), 7.55 (s, 1H), 7.51–7.43 (m, 3H), 7.42 (s, 1H), 3.93 (s, 3H), 2.77 (t, J=7.4 Hz, 2H), 2.24 (t, J=7.3 Hz, 2H), 2.11 (s, 6H), 1.63 (m, 2H), 1.47 (m, 2H). EIMS found M+=475.1657, 477.1650. C27H26ClN3O3 requires 475.1663, 477.1633.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07094798B1
Source dataset	uspto-grants-2006_08
ORD ID	ord-ef93ac7314bc40abb94057164ba9666f
Source note	uspto-grants-2006_08