反应详情

Demethylation of (173) prepared as described in example 312 with pyridine hydrochloride using the procedure described in example 81 gave (177) (72%). 1H NMR δ [(CD3)2SO] 11.70 (s, 1H), 10.98 (br s, 1H), 9.30 (br, 1H), 8.31 (s, 1H), 7.57 (dd, J=8.0, 2.2 Hz, 1H), 7.49 (s, 1H), 7.49–7.40 (m, 3H), 7.32 (s, 1H), 2.73 (t, J=7.5 Hz, 2H), 2.44–2.36 (m, 6H), 1.69–1.61 (m, 6H), 1.51 (m, 2H). The hydrochloride salt had a mp of 173–178° C. (dec). Found: C, 62.27; H, 5.22; N, 7.74. C28H26ClN3O3.HCl.H2O requires C, 62.00; H, 5.39; N, 7.75.