ethyl 2-(1-((2,2-difluorocyclopropyl)methyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methylthiazole-5-carboxylate → 2-(1-((2,2-difluorocyclopropyl)methyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methylthiazole-5-carboxylic acid

HRID 1114234Notes

Reaction equation

HRID 1114234 reaction equation
[F:1][C:2]1([F:3])[CH2:4][CH:5]1[CH2:6][N:7]1[CH2:8][CH2:9][N:10]([c:11]2[s:12][c:13]([C:14]([O:15][CH2:16][CH3:17])=[O:18])[c:19]([CH3:20])[n:21]2)[C:22]1=[O:23].[F:24][C:25]1([F:46])[CH:26]([CH2:28][n:29]2[n:30][cH:31][n:32](-[c:35]3[s:36][c:37]([C:41](=[O:42])[O:43][CH2:44][CH3:45])[c:38]([CH3:40])[n:39]3)[c:33]2=[O:34])[CH2:27]1>>[F:24][C:25]1([F:46])[CH:26]([CH2:28][n:29]2[n:30][cH:31][n:32](-[c:35]3[s:36][c:37]([C:41](=[O:42])[OH:43])[c:38]([CH3:40])[n:39]3)[c:33]2=[O:34])[CH2:27]1

Participants

3

Reactant 2

HCID 57919808ethyl 2-(1-((2,2-difluorocyclopropyl)methyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methylthiazole-5-carboxylateHCID 57919981Ethyl 2-(3-((2,2-difluorocyclopropyl)methyl)-2-oxoimidazolidin-1-yl)-4-methylthiazole-5-carboxylate

Product 1

HCID 441923722-(1-((2,2-difluorocyclopropyl)methyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methylthiazole-5-carboxylic acid

Sources & evidence

ORD record
ord-c848a60a56624f69b2c486bc9728a159
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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