Dichloromethane → 5-bromo-N-(4-fluorophenyl)-1-(4-(trifluoromethyl)-phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxamide

HRID 1114569Notes

Reaction equation

HRID 1114569 reaction equation
[Br:1][c:2]1[c:3]2[c:8]([cH:9][cH:10][cH:11]1)[CH:7]([c:12]1[cH:13][cH:14][c:15]([C:18]([F:19])([F:20])[F:21])[cH:16][cH:17]1)[NH:6][CH2:5][CH2:4]2.[Cl:32][CH2:33][Cl:34].[F:22][c:23]1[cH:24][cH:25][c:26]([N:29]=[C:30]=[O:31])[cH:27][cH:28]1>>[Br:1][c:2]1[c:3]2[c:8]([cH:9][cH:10][cH:11]1)[CH:7]([c:12]1[cH:13][cH:14][c:15]([C:18]([F:19])([F:20])[F:21])[cH:16][cH:17]1)[N:6]([C:30]([NH:29][c:26]1[cH:25][cH:24][c:23]([F:22])[cH:28][cH:27]1)=[O:31])[CH2:5][CH2:4]2

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 709554-Fluorophenyl isocyanateHCID 595362725-Bromo-1-(4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline

Product 1

HCID 595364265-bromo-N-(4-fluorophenyl)-1-(4-(trifluoromethyl)-phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxamide

Sources & evidence

ORD record
ord-573ccda64292475ea58aedcbf92cbc40
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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