1-(4-Difluoromethoxy-3-methyl-phenyl)-ethanone → (RS)-1-(3-bromo-5-ethoxymethyl-phenyl)-1-(4-difluoromethoxy-3-methyl-phenyl)-ethanol
Reaction equation
[Br:15][c:16]1[cH:17][c:18]([Br:26])[cH:19][c:20]([CH2:22][O:23][CH2:24][CH3:25])[cH:21]1.[CH2:27]([Li:28])[CH2:29][CH2:30][CH3:31].[F:1][CH:2]([O:3][c:4]1[c:5]([CH3:13])[cH:6][c:7]([C:10]([CH3:11])=[O:12])[cH:8][cH:9]1)[F:14]>>[F:1][CH:2]([O:3][c:4]1[c:5]([CH3:13])[cH:6][c:7]([C:10]([CH3:11])([OH:12])[c:16]2[cH:17][c:18]([Br:26])[cH:19][c:20]([CH2:22][O:23][CH2:24][CH3:25])[cH:21]2)[cH:8][cH:9]1)[F:14]Participants
4
Sources & evidence
- ORD record
- ord-68e1eed32e4d41649c4a7b7589418812
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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